Our neuron biosensing platform is a hybrid electronic/biological device designed to allow for signal recording from a variety of cultures via neurons. Allowing real-time monitoring of electrophysiological signals and biomolecular activity. It can be used for fundamental neuroscience research, drug discovery, biomolecule sensing, and even as a foundation for future brain-computer interface (BCI) applications.

We’re currently in the prototype stage. If you’d like to become an early tester or discuss collaboration opportunities, please reach out at alec@plusten.ai. We’re eager to gather feedback from researchers and innovators who want to explore the platform’s potential.

Neurons offer a biologically relevant readout for electrophysiological activity and can be engineered for specific biomolecule detection through custom receptor expression. Unlike purely electronic sensors, neuronal networks can respond to subtle chemical or environmental changes in a way that mimics real biological systems.

Our platform can be adapted for a wide range of applications, including drug toxicity screening, neurodegenerative disease modeling, neural network behavior studies, and biomolecule sensing (via custom receptor expression). We’re also exploring how it could serve as a proof-of-concept for future BCI research by leveraging axons as ‘biological wires.’

The device is designed to fit into standard incubators and work with common lab instruments, including microscopes and electrophysiology amplifiers. We’ll provide detailed specifications on connections and mounting once the prototype is finalized.

We aim for an intuitive workflow, so our devices come pre-seeded and ready to go. You maintain them with standard cell culture techniques, and connect the electronics to your computer for data acquisition system and real-time monitoring via our software suite. While any new technology has a learning curve, our goal is to keep it as straightforward as possible.

Absolutely. We understand that each lab’s research questions may vary. We can discuss tailored electrode layouts, well dimensions, or even specialized coatings. Additonally we can build the sensing neuronsa into a variety of custom devices. Feel free to contact us at alec@plusten.ai to explore custom solutions.

Our focus is on leveraging neurons themselves as the sensing element. While many organ-on-a-chip systems rely on microfluidic networks and physical sensors, our platform fosters direct neuron-electronics interfacing. This unlocks unique possibilities in electrophysiological signal capture, neural network modeling, and BCI-oriented research.